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To do this, we used an analysis of covariance with unequal slopes to test the effect of treatment on cumulative oligodendrocyte gain while considering the effect of cumulative oligodendrocyte loss and the interaction between cumulative oligodendrocyte loss and treatment (see Statistics and modeling in Methods) (Fig

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Finally, due to the nature of cross-sectional study designs, we cannot interpret the causality of the observed association between VitB12 and insomnia