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Conversely, in ovarian serous carcinoma (OSC), NAC-derived cysteine appears to be efficiently utilized for GSH biosynthesis without significantly impairing chemotherapeutic activity, suggesting a more nuanced subtype-specific response to antioxidant therapy

& Kanthasamy, A

Discovering the anticancer potential of non-oncology drugs by systematic viability profiling

The SAR and mechanistic insights emerging from the MK-8189 highlight several key design principles
