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Description
Once absorbed, all-trans retinoic acid binds to retinoic acid receptors (RARs) inside the cell nucleus
Acute and chronic As toxicity is related to the dysfunctions of numerous vital enzymes
Walsh and Selkoe, 2007
Blood flow is sluggish in the normal spleen and bone marrow, which are prominently affected in sickle cell disease, and also in vascular beds that are inflamed
