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Trx1 can bind to GR and enhance the response of the cells to glucocorticoids (114)

GLS1 interacts with Kelch-like ECH-associated protein 1 (KEAP1) to release nuclear factor erythroid 2-related factor 2 (NRF2), enhancing antioxidant defenses and promoting chemotherapy resistance, while glutamine-derived glutamate activates mTORC1 via Rag GTPases [62,94]

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