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Abstract The 2024 NICE guidelines on vitamin B 12 deficiency have significant implications for the diagnosis and management of pernicious anaemia (PA), the commonest non-dietary cause of such deficiency

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The principal hypothesis to be tested in this study was whether exposure to ARA 290, a molecule demonstrating tissue-protective, antiinflammatory and reparative activities in numerous preclinical models, would stimulate nerve fiber regrowth with associated improvements in pain and other sensory symptoms, and autonomic function