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In addition, the kinetics of antigen-specific T cell responses varied in LC, with individuals presenting similar antigen-specific T cell responses at the early and intermediate phases of convalescence and even elevated responses at a later time point [184]

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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS

In an unbound state, the AR complexes with heat-shock, chaperone and co-chaperone proteins (such as HSP90, HSP70, and p23), which helps to maintain the apo state of the AR in a state competent to bind ligand (Figure 1A) 73