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Coleman and Blass (108) first identified the presence of lactic acidosis in a small set of patients in 1985, with Lombard (109) later proposing that ASD may be at least partially due to abnormal neuronal oxidative phosphorylation

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Kinetic profiles after the consumption of legume-derived polyphenols typically show biphasic plasma peaks: an early peak (13 h) from small intestinal absorption of free, low-molecular-weight compounds and a later peak (410 h or even later) reflecting the absorption of microbial catabolites from the colon (Williamson, 2025)

Conversely, a biochemical compound that was lower in the diet might be detected at lower levels in the dogs