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Take Creatine before, during, or after your workout The most often-cited studies of creatine monohydrates benefits suggest that it is more beneficial to consume after a workout to achieve the greatest increases in muscle size, and subsequent exercise performance

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To further confirm Nrf2s involvement in the ER calcium regulation process via GPX8, in the same study, after silencing Nrf2 in HeLa cells, GPX8 mRNA and protein levels also decreased, resulting in elevated ER and cytosolic calcium levels at rest and increased histamine-induced ER calcium release (Granatiero et al., 2019)

Cheng Y, Dai X, Yang T, Zhang N, Liu Z, Jiang Y