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16 The REDEFINE 1 trial demonstrated that once-weekly subcutaneous cagrilintide/semaglutide (CagriSema) 2.4 mg/2.4 mg for 68 weeks resulted in weight loss of 22.7% compared with 16.1% with semaglutide 2.4 mg, 11.8% with cagrilintide 2.4 mg, and 2.3% with placebo in adults with overweight or obesity, without diabetes