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Translational interpretation must therefore remain cautious: while animal and in vitro models provide strong mechanistic plausibility, definitive connections to human disease will require longitudinal biomonitoring and well-designed epidemiological studies

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Homocysteine, vitamin B 12 , and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: baseline characteristics in subjects of the Australian Imaging Biomarker Lifestyle study