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In a subset of rat layer 5 ACC pyramidal neurons, DOR, but not MOR, activation produces direct hyperpolarization, presumably through a postsynaptic increase in potassium conductance (Tanaka and North, 1994)

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis

These would involve a progression of more demanding/informative studies as has been done measuring dopaminergic function: initially case-control studies of treated schizophrenia, followed by antipsychotic-nave schizophrenia, bipolar-I with psychosis and high-risk psychosis (measuring the strength and specificity of NMDA hypofunction in schizophrenia)

Isolated brain involves submerging the brain in oxygenated artificial cerebrospinal fluid
