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In turn, this inflammatory milieu, characterized by the production of inflammatory and pro-fibrotic cytokines, further exacerbates microvascular endothelial cell injury and apoptosis (174, 175), creating a vicious cycle that culminates in thrombosis, inflammation, and a myriad of clinical manifestations ranging from skin to parenchymal organs (174, 176)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Miric DJ, Kisic BM, Filipovic-Danic S, Grbic R, Dragojevic I, Miric MB, Puhalo-Sladoje D