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Description
Antioxidant and oxidative stress: A mutual interplay in age-related diseases

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167,168 In an EMT, epithelial cells lose apicobasal polarity and adhesive contacts while gaining actin stress fibers, anteroposterior polarity, motility, and remodeled contacts with neighboring cells and the ECM

Compared to strong oxidants like the hydroxyl radical, 4-HNE and MDA are relatively stable and able react with macromolecules, such as proteins distal to the site of origin
