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(176) demonstrated that nanoreactors combining dihydroquercetin and Pt enzymes show synergistic effects in reducing OS and controlling the inflammatory microenvironment, thus preventing neuronal damage

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The cytoprotective (reduced reactive oxygen species and reduced cell senescence) effects of ergothioneine on endothelial cells exposed to hyperglycaemic conditions have been shown to be dependent on sirtuin 1 and sirtuin 6 activities and their cellular targets (Reference DOnofrio, Servillo and Giovane89) , which notably include NF- B, the aforementioned transcriptional regulator of SLC22A4 (Reference Maeda, Hirayama and Kobayashi63)