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Description

In addition, other environmental triggers influence the development of narcolepsy as novel unknown environmental factors may also cause narcolepsy in the future, so it is critical to investigate those factors from time to time [6]

Normally, BCAAs (e.g., valine, leucine and isoleucine) can be converted to their corresponding branched-chain keto acids that in turn can be converted to branched-chain CoA, which can also bind carnitine to form branched-chain acylcarnitines (BCACs), such as propionylcarnitine (C3-carnitine), succinylcarnitine (C4DC-carnitine) and isovalerylcarnitine (isoC5-carnitine), which are involved in the energy production process of cells [10]

Three components are involved in this transporting system: CPTI, the carnitine acylcarnitine translocase (CACT) and CPTII