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Description
Avoid ketorolac use during the third trimester of pregnancy (starting at 30 weeks of gestation) due to the risk of premature closure of the fetal ductus arteriosus and persistent pulmonary hypertension in the neonate (2,3,5,6)
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APAP activation would be shown to be catalysed mainly by CYP2E1, CYP1A2 and CYP3A4, with CYP2E1 predominating at high concentrations
