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For example, mitochondria are home to several core metabolic pathways including the citric acid cycle (tricarboxylic acid cycle, Krebs cycle), oxidative phosphorylation, and the beta-oxidation pathway for fatty acid degradation
Consumption of a high fat diet results in a surplus of NADH and FADH 2 that then increases the flux through the ETC with a resultant increase in ROS generation
The consistency of the preclinical data across multiple studies and laboratories supports the mechanistic hypothesis
