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(Note: this timing rationale is practitioner-derived and anecdotal

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Moreover, in animals, NNMT knockdown improves insulin sensitivity, overnight fasting glucose levels, and glucose tolerance and reduces the relative fat mass [11, 14]

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This could explain why tirzepatide (which stimulates the GIP pathway in addition to GLP -1) can be administered at higher doses than semaglutide (which only stimulates GLP-1), without amplifying the side effects typical of GLP-1 agonists (nausea, vomiting)

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It appears to promote the production of GH and may potentially stimulate GH synthesis

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