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Cerebral metabolism in major depressive disorder: a voxel-based meta-analysis of positron emission tomography studies

[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Orth M., Schapira A.H
The antidepressant response to LAC occurs after 3 days of administration and lasts for at least 14 days, whereas the action of standard antidepressant drugs (fluoxetine and clomipramine) requires 14 days of consecutive administration and disappears after drug withdrawal in the same rodent models [30, 34]

Lancet 383, 20652072