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The exact frequency may be adjusted based on how severe the deficiency is and what the veterinarian recommends to support healthy recovery and stable vitamin levels

The peptide is small enough (three amino acids plus a copper ion) to penetrate the stratum corneum, particularly when formulated with phospholipid-based delivery systems that enhance dermal absorption

Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity