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(2013, Nature Medicine) found that L-carnitine is metabolized by intestinal microbiota to trimethylamine-N-oxide (TMAO), a proatherogenic substance associated with increased CVD risk
The excess accumulation of labile iron in the mitochondria of FRDA patients can react with the mitochondrial reactive oxygen species (ROS) that is inevitably present in these organelles due to occasional leakages of electron(s) from the electron transport chain (Zhao et al., 2019)
