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These treatment-related complications, if not properly managed, can lead to nutritional deterioration, potentially establishing a detrimental cycle that may compromise clinical outcomes (6)

This leads to the buildup of lipid peroxidation to a level that triggers cell death, which can also be directly caused by the inhibition of GPX4 enzymes (e.g., GSH peroxidase 4 inhibitors like RSL3) (57)

See Table 2 for full details of probe numbers, P-values and median false discovery rates