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The BBB consists of firmly sealed cellular junctions on CNS blood capillaries that protect the brain from toxins and polar pharmaceuticals [10, 11]

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Modulation of Autophagy Autophagy, also called partial macro-autophagy, is a catabolic process that supports cellular homeostasis and is implemented with the participation of lysosomes and the ubiquitinproteasome system [103]

315 Bimolecular outer-sphere electron-transfer processes are generally slower than inner-sphere electron-transfers but can provide a viable reduction mechanism for platinum(IV) agents in which ligands that are capable of forming a bridge to an electron transfer agent are trans to firmly bound ligands