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A fast, decisive insertion passes through the pain-sensitive skin layer in a fraction of a second
copri intervention, mediated through gut barrier repair, significantly restores bone homeostasisincluding enhanced bone density and bone remodeling balanceand promotes osteoblast ferroptosis resistance in both in vitro cellular models (e.g., MC3T3-E1 cultures) and in vivo animal models (e.g., OA mice) (Li et al., 2025)
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