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The organic phase was combined, washed with saturated brine, dried over anhydrous sodium sulfate, filter over a silica gel column (dichloromethane: methanol, 10:1) and eluted to get the intermediate ( S )-4, enantiomeric excess (ee) determined by HPLC, 98% ee
These patients should use b12 supplementation regardless of whether their semaglutide formulation includes it
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Endocrinology, 142(12), 51825189
