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For Cu-Zn-SOD, the catalytic site is the tetracoordinate structure of copper ion (Cu 2+ ) with four imidazolyls of histidine residues 14,15,16 , and the coordinated zinc ion (Zn 2+ ) plays the role in maintaining structural integrity 17,18,19
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Resveratrol is a polyphenolic stilbenoid found in grapes, pine nuts, peanuts and red wine and shows antioxidant, anti-inflammatory and neuroprotective properties [132, 133]
