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Since the three resulting models from this work are QSAR models trained on a dataset with only the strongest acidic and basic pKas, they do not provide pKas for all ionization sites for multiprotic compounds

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Common research protocols use 1-3 mg daily via subcutaneous injection

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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal [lower than normal], further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly

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