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Discussion A mathematical modelling approach was deployed to simulate GSH depletion as a function of doxorubicin redox metabolism

In studies of non-alcoholic steatohepatitis due to oxidative stress, overexpression of GPX7 in LX-2 cells will result in inhibition of ROS production and a decrease in the expression of profibrotic and pro-inflammatory genes (Kim et al., 2020)

Solomon J, Festa MC, Chatzizisis YS, et al

Be sure to also read the companion article, Acknowledgment Special thanks to Jennifer Neel, DVM, DACVP, assistant professor of clinical pathology, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, for providing the micrographs in this article
