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We assume a 22 g dose of APAP followed by an infusion of 36 mM NAC (the standard rescue dose[1]) over a 1 hour period starting at various times after the APAP dose
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10.4103/NRR.NRR-D-24-00112 125 ZhuX.LuH.JiaH.WeiX.XueJ.LiW.et al (2025)

Neither TB-4 nor BPC-157 "stays local" both enter systemic circulation within minutes but first-pass tissue concentration is higher at the injection site before systemic dilution, which matters disproportionately for TB-4's concentration-dependent mechanism
