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In addition, these investigations predominantly focused on the GBM subtype of brain cancer, thereby restricting the extrapolation of their findings to other histological subtypes
Some ferroptosis-targeting agents have poor pharmacokinetic properties, such as low solubility, high metabolic clearance, low cellular permeability, and short half-lives ( Figure 7 )
[67] Cardiovascular disease [edit] Increased IGF1 levels are associated with a 16% lower risk of cardiovascular disease and a 28% reduction of cardiovascular events
