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Description
These pathways can produce overlapping symptoms but require different clinical questions

Sleep disruption on tirzepatide typically appears during the first 2-4 weeks or after dose increases and resolves as the body adapts
185,186,187 In contrast to the positive effect of NAD + on DNA repair, NADP + suppresses the ADP-ribosylation-mediated DNA damage repair via functioning as an endogenous inhibitor of PARPs

10.1080/19490976.2023.2181922 13 CaniP
