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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Gherasim et al., 2013), the most common B12 form in both food and human plasma (Obeid et al., 2015)

In view of the significant heterogeneity observed in mitochondria, it is essential to employ comprehensive methodologies, encompassing both domestic and international gene technology, multi-omics technology, single-cell sequencing, and other techniques

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