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Glutamate-cysteine ligase (GCL) is the first and rate-limiting step in the synthesis of the major cellular antioxidant glutathione (GSH)

The liposomal format is formulated for rapid delivery and efficient absorption

Then they immobilize it onto glutathione beads using the same GST-glutathione interaction

Here, the authors show that early-life high-fat/high-sugar diet induces sex-specific alterations in adult feeding behavior, hypothalamic transcriptome and blood metabolome, with Bifidobacterium longum and prebiotic FOS+GOS administration restoring these effects via distinct mechanisms, highlighting their therapeutic potential.