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Preclinical research suggests that luteolin effectively exerts antidepressant and neuroprotective effects by inhibiting monoamine neurotransmitter reuptake to increase their levels in the brain (Fig

Additionally, Nrf2 overactivation in hepatoma cells inhibits the pro-inflammatory response by suppressing cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expression, creating a favorable environment for malignant cell survival and protecting them from oxidative stress [138]

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Pietrogrande L, Raimondo E

Br J Cancer 128, 421425, doi: 10.1038/s41416-023-02158-5 (2023)