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Similar to a Phe-reduced diet, if co-administered with neurotransmitter precursors, a sapropterin dihydrochloride treatment consistently improved almost all clinical symptoms in PTPSD, DHPRD (see comment below), and AR-GTPCHD, including movement disorders (dystonia, oculogyric crises, choreoathetosis, tremor, hypotonia, hypertonia, rigidity), epileptic seizures, sleep problems, gastrointestinal disturbances (hypersalivation, swallowing difficulties), anthropometric parameters, developmental delay, and behavioural abnormalities