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For example, the fungal allergen alkaline protease 1 from Aspergillus directly damages bronchiolar cellcell junctions in murine models by inducing calcium influx via the calcineurin pathway, thereby promoting Th cellmediated pulmonary eosinophilia (Wiesner et al., 2020)

However, the protective effect diminished over time, with no significant difference in overall incidence rates between the 287-CAR CD8 T cell therapy group and the control group at 30 weeks (76)

It is unclear whether any benefit would be seen were glibenclamide started following the onset of infection in nondiabetic patients

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