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Disruption of mitochondrialsarcoplasmic reticulum (SR) crosstalk exacerbates this cycle, weakening excitationcontraction coupling and reducing contractile reserve (Zorov et al., 2014
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doi: 10.3389/fmed.2021.645187 6
Moreover, folate metabolism also provided critical intermediates for NADPH production and GSH synthesis in metastatic melanoma cells [32]
