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Introduction Diabetes mellitus remains one of the leading causes of deaths worldwide (Figure 1) ( FIGURE 1 There has been a general interest in pharmacological compounds with strong antioxidant and anti-inflammatory properties for their protective effects against diabetes-associated cardiovascular complications ( There is currently a considerable interest in understanding the therapeutic role of herbs and supplements against diabetes and CVD-related complications ( Methodology Supplementary file 1 contains the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines that were followed to prepare the manuscript

Przedborski S, Donaldson DM, Murphy PL, Hirsch O, Lange D, Naini AB, et al

The key benefit of B12 is that the proper amount can relieve a wide range of symptoms

For most patients with congenital GHD, GH therapy will lead to significant catch-up growth but in patients with radiation induced GH deficiency catch up growth is rare (228,229)