glutathione and dystonia Dysregulation of Homeostasis in Neurodegenerative Diseases Alterations in the glutathione and
Description
Though we did not distinguish the extent to which cysteine restriction influences these two routes of cytosolic cluster synthesis, our findings strongly reflect previous work demonstrating a sensitivity of the CIA to GSH limitation, as GSH is required in the assembly and maturation of cytosolic clusters 77,78
Together, they drive syn misfolding, aggregation, and neuronal degeneration
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doi: 10.1111/j.1476-5381.1992.tb14230.x
