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PDH-dependent generation of acetyl-CoA is crucial for H3K27 histone acetylation and remodeling of the genetic landscape associated with CD4 + T cell activation [115]

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Vitamin B2 (Riboflavin) Plays a role in cellular energy production and antioxidant pathways, supporting mitochondrial function and tissue repair

An association with vitamin B 12 deficiency in non-metformin-exposed individuals and genotype was also demonstrated for both AG (OR 1.11 [95% CI 0.99, 1.24], I 2 =19.3%) and AA (OR 1.42 [95% CI 1.21, 1.67], I 2 =14.4%) genotypes but ORs were lower than in metformin-exposed individuals