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Experiments in perfused rat livers have shown that a slight alkali increase in extracellular pH (0.4 units) can enhance mitochondrial import of glutamine into hepatocytes, as H + is transported externally to possibly reduce extracellular pH and maintain equilibrium
doi: 10.1016/j.freeradbiomed.2004.01.001
They also showed that the addition of a P-glycoprotein inhibitor (verapamil) significantly reduced the LC 50 (the concentration that is lethal to 50% of the individuals exposed) values of ivermectin
Key oxidative stress markers include glutathione levels, malondialdehyde, and 8-oxoguanine
