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If H 2 O 2 remains in the mitochondrial matrix it reacts with the ferrous (Fe 2+ ) iron via the Fenton reaction yielding the hydroxyl free radical which is highly reactive toward DNA and polyunsaturated fatty acids (PUFA)

Research Background & Mechanistic Focus Current research use centers on coordinated cytoskeletal, cellular-migration, and structural-response signaling models, comparative presentation or formulation behavior where applicable, and controlled experimental models designed to evaluate compound-specific signaling activity within non-clinical laboratory systems

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