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Keratinocyte differentiation markers including keratin 1, keratin 10, and involucrin demonstrate appropriate expression patterns, indicating that GHK-Cu promotes not merely rapid re-epithelialization but proper structural and functional restoration of the epidermal barrier

doi: 10.1016/j.ajcnut.2022.10.012

By binding to the IGF-1 receptor (IGF1R), IGF-1 initiates the phosphorylation of phosphatidylinositol 2-phosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which activates downstream signaling pathways involving AKT and the mammalian target of rapamycin (mTOR)
