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We observed significantly lower levels of PI(3)P, PI(3,4)P 2 , and PI(3,4,5)P 3 , suggesting IGF-1R regulates the PI-3 kinases

10.1038/nrm2335 113 XingN.DuQ.GuoS.XiangG.ZhangY.MengX.et al (2023)

170 These findings suggest that the TGF-1/Smad3 signaling pathway may have a protective effect by promoting -catenin expression and reducing apoptosis

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