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Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

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For instance, anabolism consumes energy in the form of ATP or NADH to synthesize biomolecules such as DNA and proteins, while catabolic reactions break down macromolecules, releasing energy in the form of ATP or NADH, which can be reutilized to generate NAD + 2