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The experts agreed on the need for educational and organizational changes in the current practices

In Phase I, enzymes modify toxins, often making them more reactive

In a recent review on herbicide resistance, it is mentioned that GSTs are the natural inbuilt defense system in plants against oxidative stress caused by herbicide treatment (Nakka et al

Infants under 2 years of age have been described as more vulnerable to mucolytic-related adverse events, which may include paradoxically increased bronchorrhea and acute respiratory distress during respiratory tract infections.22,23 These risks may be dose-dependent and are likely influenced by anatomical and physiological differences in infants.22,101 Such concerns led French and Italian drug agencies to restrict the licenses for NAC and carbocysteine in children under 2 years, advising against their routine administration in this age group.22,101 This regulatory action underscores the particular vulnerability of the paediatric population and highlights the importance of careful, evidence-based dosing practices.22 According to the Centers for Disease Control and Prevention growth charts (Figure 3), the median weight of a 4-year-old child is approximately 16 kg, whereas a 9-year-old weighs around 29 kg.102,103 Administering the same dose across this broad age and weight range disproportionately exposes younger, lighter children to higher per-kilogram doses