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Description
This promotes mitochondrial fission and dysfunction, leading to CH (226, 227)

For example, C9orf72 is part of a protein complex that controls autophagosome formation and lysosomal fusion, and when impaired, leads to accumulation of TDP-43 aggregates [222]

Defects in fatty acid oxidation [30] or Complex IV in a mixed population of mitochondria isolated from aging heart [3133] were localised specifically to the IFM [15]

creatine cycling UCP1 uncouples oxidative phosphorylation by dissipating proton gradients, directly converting chemical energy to heat
