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For a deeper dive into this science, you can read Why Research Peptides Are Typically Lyophilized

Eluted fractions consisting of complex were pooled and concentrated to ~4 mg/mL and flash frozen by liquid nitrogen as aliquots and stored at 80 C until use

However, it would appear that a small amount of cobalamin can be synthesized by the intestinal flora present in an area unable to absorb it [2], therefore making the vitamin unavailable

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