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In many cell types, pyruvate carboxylation to oxaloacetate is suppressed, thereby rendering them reliant on glutamine catabolism to replenish the oxaloacetate that can condense with acetylCoA to produce citrate and drive the TCA cycle (DeBerardinis et al , 2007)
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In addition, DeepDIA can select a list of target peptides to be included in in silico spectral libraries from protein sequence databases, e.g
Therefore, if the intermediate toxins that come from Phase 1 are not eliminated in Phase 2, it will then become carcinogens and in turn be extremely harmful
