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Ergothioneine Oxidation in the protection against High-Glucose Induced Endothelial Senescence: Involvement of SIRT1 and SIRT6

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The main metabolic pathways include hydrolysis, glucuronidation, sulfation, and dehydrogenation

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These cytokines have been confirmed to contribute to the SG fibrosis by enhancing the local chronic inflammatory environment and inducing the activation of myofibroblasts, especially the macrophage-derived TGF- (121)

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